What shortcut is used to activate VoiceOver on a Mac?

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The shortcut to activate VoiceOver on a Mac is Cmd + F5. This combination is designed specifically for enabling VoiceOver, which is the built-in screen reader for macOS. By using this keyboard shortcut, users can quickly turn on or off the VoiceOver feature, making it accessible for individuals who have visual impairments or prefer to use auditory feedback when interacting with their devices. Activating VoiceOver allows users to navigate their Mac more easily using keyboard commands, as well as providing verbal descriptions of on-screen content, which enhances the overall accessibility of the operating system for those who rely on screen readers.

The other combinations provided do not serve that particular function for toggling VoiceOver on or off. Thus, the choice of Cmd + F5 is the specific and correct answer related to activating the screen reader functionality on a Mac.